For the rest of us, however, it is likely that the only knot we tie with frequency is the daily task of tying one's shoes. (By the way, WonderHowTo has that task well covered, as well).
According to Runners World, there is a right way (and wrong way) to tie your shoes. Go with the reef knot and you will have a neat, balanced, self-tightening knot. Go with the granny knot and you will likely have a sloppy knot, destined to become untied.
Instructions via Runners World (click through for additional instructional video):